Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress
Identifieur interne : 002116 ( Main/Exploration ); précédent : 002115; suivant : 002117Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress
Auteurs : Daniel T. Shaughnessy [États-Unis] ; Kimberly Mcallister [États-Unis] ; Leroy Worth [États-Unis] ; Astrid C. Haugen [États-Unis] ; Joel N. Meyer [États-Unis] ; Frederick E. Domann [États-Unis] ; Bennett Van Houten [États-Unis] ; Raul Mostoslavsky [États-Unis] ; Scott J. Bultman [États-Unis] ; Andrea A. Baccarelli [États-Unis] ; Thomas J. Begley [États-Unis] ; Robert W. Sobol [États-Unis] ; Matthew D. Hirschey [États-Unis] ; Trey Ideker [États-Unis] ; Janine H. Santos ; William C. Copeland [États-Unis] ; Raymond R. Tice [États-Unis] ; David M. Balshaw [États-Unis] ; Frederick L. Tyson [États-Unis]Source :
- Environmental Health Perspectives [ 0091-6765 ] ; 2014.
Abstract
Background: Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP production but also through metabolites generated in the tricarboxylic acid cycle, as well as mitochondria–nuclear signaling related to mitochondria morphology, biogenesis, fission/fusion, mitophagy, apoptosis, and epigenetic regulation.
Objectives: We investigated the concept of bidirectional interactions between mitochondria and cellular pathways in response to environmental stress with a focus on epigenetic regulation, and we examined DNA repair and DDR pathways as examples of biological processes that respond to exogenous insults through changes in homeostasis and altered mitochondrial function.
Methods: The National Institute of Environmental Health Sciences sponsored the Workshop on Mitochondria, Energetics, Epigenetics, Environment, and DNA Damage Response on 25–26 March 2013. Here, we summarize key points and ideas emerging from this meeting.
Discussion: A more comprehensive understanding of signaling mechanisms (cross-talk) between the mitochondria and nucleus is central to elucidating the integration of mitochondrial functions with other cellular response pathways in modulating the effects of environmental agents. Recent studies have highlighted the importance of mitochondrial functions in epigenetic regulation and DDR with environmental stress. Development and application of novel technologies, enhanced experimental models, and a systems-type research approach will help to discern how environmentally induced mitochondrial dysfunction affects key mechanistic pathways.
Conclusions: Understanding mitochondria–cell signaling will provide insight into individual responses to environmental hazards, improving prediction of hazard and susceptibility to environmental stressors.
Citation: Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. 2014. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect 122:1271–1278;
Url:
DOI: 10.1289/ehp.1408418
PubMed: 25127496
PubMed Central: 4256704
Affiliations:
- États-Unis
- Californie, Caroline du Nord, Iowa, Massachusetts, Pennsylvanie, État de New York
- Chapel Hill (Caroline du Nord), Iowa City
- Université de Caroline du Nord à Chapel Hill, Université de l'Iowa
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001F33
- to stream Pmc, to step Curation: 001F07
- to stream Pmc, to step Checkpoint: 000C82
- to stream Ncbi, to step Merge: 002F72
- to stream Ncbi, to step Curation: 002F72
- to stream Ncbi, to step Checkpoint: 002F72
- to stream Main, to step Merge: 002204
- to stream Main, to step Curation: 002116
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress</title><author><name sortKey="Shaughnessy, Daniel T" sort="Shaughnessy, Daniel T" uniqKey="Shaughnessy D" first="Daniel T." last="Shaughnessy">Daniel T. Shaughnessy</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Mcallister, Kimberly" sort="Mcallister, Kimberly" uniqKey="Mcallister K" first="Kimberly" last="Mcallister">Kimberly Mcallister</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Worth, Leroy" sort="Worth, Leroy" uniqKey="Worth L" first="Leroy" last="Worth">Leroy Worth</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Haugen, Astrid C" sort="Haugen, Astrid C" uniqKey="Haugen A" first="Astrid C." last="Haugen">Astrid C. Haugen</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Meyer, Joel N" sort="Meyer, Joel N" uniqKey="Meyer J" first="Joel N." last="Meyer">Joel N. Meyer</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Nicholas School of the Environment, Duke University, Durham, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Nicholas School of the Environment, Duke University, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Domann, Frederick E" sort="Domann, Frederick E" uniqKey="Domann F" first="Frederick E." last="Domann">Frederick E. Domann</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Van Houten, Bennett" sort="Van Houten, Bennett" uniqKey="Van Houten B" first="Bennett" last="Van Houten">Bennett Van Houten</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mostoslavsky, Raul" sort="Mostoslavsky, Raul" uniqKey="Mostoslavsky R" first="Raul" last="Mostoslavsky">Raul Mostoslavsky</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bultman, Scott J" sort="Bultman, Scott J" uniqKey="Bultman S" first="Scott J." last="Bultman">Scott J. Bultman</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Baccarelli, Andrea A" sort="Baccarelli, Andrea A" uniqKey="Baccarelli A" first="Andrea A." last="Baccarelli">Andrea A. Baccarelli</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Begley, Thomas J" sort="Begley, Thomas J" uniqKey="Begley T" first="Thomas J." last="Begley">Thomas J. Begley</name><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>SUNY College of Nanoscale Science and Engineering, Albany, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>SUNY College of Nanoscale Science and Engineering, Albany, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Sobol, Robert W" sort="Sobol, Robert W" uniqKey="Sobol R" first="Robert W." last="Sobol">Robert W. Sobol</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hirschey, Matthew D" sort="Hirschey, Matthew D" uniqKey="Hirschey M" first="Matthew D." last="Hirschey">Matthew D. Hirschey</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Duke University Medical Center, Durham, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University Medical Center, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Ideker, Trey" sort="Ideker, Trey" uniqKey="Ideker T" first="Trey" last="Ideker">Trey Ideker</name><affiliation><nlm:aff id="aff11"><addr-line>Department of Medicine, and</addr-line></nlm:aff><wicri:noCountry code="subfield">and</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>Department of Bioengineering, University of California San Diego, La Jolla, California, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of California San Diego, La Jolla, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Santos, Janine H" sort="Santos, Janine H" uniqKey="Santos J" first="Janine H." last="Santos">Janine H. Santos</name><affiliation><nlm:aff id="aff13"><addr-line>Laboratory of Molecular Carcinogenesis, and</addr-line></nlm:aff><wicri:noCountry code="subfield">and</wicri:noCountry></affiliation></author><author><name sortKey="Copeland, William C" sort="Copeland, William C" uniqKey="Copeland W" first="William C." last="Copeland">William C. Copeland</name><affiliation wicri:level="2"><nlm:aff id="aff14"><addr-line>Laboratory of Molecular Genetics, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Molecular Genetics, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Tice, Raymond R" sort="Tice, Raymond R" uniqKey="Tice R" first="Raymond R." last="Tice">Raymond R. Tice</name><affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Biomolecular Screening Branch, Division of the National Toxicology Program, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomolecular Screening Branch, Division of the National Toxicology Program, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Balshaw, David M" sort="Balshaw, David M" uniqKey="Balshaw D" first="David M." last="Balshaw">David M. Balshaw</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Tyson, Frederick L" sort="Tyson, Frederick L" uniqKey="Tyson F" first="Frederick L." last="Tyson">Frederick L. Tyson</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25127496</idno><idno type="pmc">4256704</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256704</idno><idno type="RBID">PMC:4256704</idno><idno type="doi">10.1289/ehp.1408418</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001F33</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001F33</idno><idno type="wicri:Area/Pmc/Curation">001F07</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001F07</idno><idno type="wicri:Area/Pmc/Checkpoint">000C82</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000C82</idno><idno type="wicri:Area/Ncbi/Merge">002F72</idno><idno type="wicri:Area/Ncbi/Curation">002F72</idno><idno type="wicri:Area/Ncbi/Checkpoint">002F72</idno><idno type="wicri:doubleKey">0091-6765:2014:Shaughnessy D:mitochondria:energetics:epigenetics</idno><idno type="wicri:Area/Main/Merge">002204</idno><idno type="wicri:Area/Main/Curation">002116</idno><idno type="wicri:Area/Main/Exploration">002116</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress</title><author><name sortKey="Shaughnessy, Daniel T" sort="Shaughnessy, Daniel T" uniqKey="Shaughnessy D" first="Daniel T." last="Shaughnessy">Daniel T. Shaughnessy</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Mcallister, Kimberly" sort="Mcallister, Kimberly" uniqKey="Mcallister K" first="Kimberly" last="Mcallister">Kimberly Mcallister</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Worth, Leroy" sort="Worth, Leroy" uniqKey="Worth L" first="Leroy" last="Worth">Leroy Worth</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Haugen, Astrid C" sort="Haugen, Astrid C" uniqKey="Haugen A" first="Astrid C." last="Haugen">Astrid C. Haugen</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Meyer, Joel N" sort="Meyer, Joel N" uniqKey="Meyer J" first="Joel N." last="Meyer">Joel N. Meyer</name><affiliation wicri:level="2"><nlm:aff id="aff2"><addr-line>Nicholas School of the Environment, Duke University, Durham, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Nicholas School of the Environment, Duke University, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Domann, Frederick E" sort="Domann, Frederick E" uniqKey="Domann F" first="Frederick E." last="Domann">Frederick E. Domann</name><affiliation wicri:level="4"><nlm:aff id="aff3"><addr-line>Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Van Houten, Bennett" sort="Van Houten, Bennett" uniqKey="Van Houten B" first="Bennett" last="Van Houten">Bennett Van Houten</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Mostoslavsky, Raul" sort="Mostoslavsky, Raul" uniqKey="Mostoslavsky R" first="Raul" last="Mostoslavsky">Raul Mostoslavsky</name><affiliation wicri:level="2"><nlm:aff id="aff5"><addr-line>Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Bultman, Scott J" sort="Bultman, Scott J" uniqKey="Bultman S" first="Scott J." last="Bultman">Scott J. Bultman</name><affiliation wicri:level="4"><nlm:aff id="aff6"><addr-line>Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region><settlement type="city">Chapel Hill (Caroline du Nord)</settlement></placeName><orgName type="university">Université de Caroline du Nord à Chapel Hill</orgName></affiliation></author><author><name sortKey="Baccarelli, Andrea A" sort="Baccarelli, Andrea A" uniqKey="Baccarelli A" first="Andrea A." last="Baccarelli">Andrea A. Baccarelli</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Environmental Epigenetics, Exposure Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Begley, Thomas J" sort="Begley, Thomas J" uniqKey="Begley T" first="Thomas J." last="Begley">Thomas J. Begley</name><affiliation wicri:level="2"><nlm:aff id="aff8"><addr-line>SUNY College of Nanoscale Science and Engineering, Albany, New York, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>SUNY College of Nanoscale Science and Engineering, Albany, New York</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Sobol, Robert W" sort="Sobol, Robert W" uniqKey="Sobol R" first="Robert W." last="Sobol">Robert W. Sobol</name><affiliation wicri:level="2"><nlm:aff id="aff4"><addr-line>University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Pittsburgh Cancer Institute, Hillman Cancer Center, University of Pittsburgh, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff9"><addr-line>Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hirschey, Matthew D" sort="Hirschey, Matthew D" uniqKey="Hirschey M" first="Matthew D." last="Hirschey">Matthew D. Hirschey</name><affiliation wicri:level="2"><nlm:aff id="aff10"><addr-line>Duke University Medical Center, Durham, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Duke University Medical Center, Durham, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Ideker, Trey" sort="Ideker, Trey" uniqKey="Ideker T" first="Trey" last="Ideker">Trey Ideker</name><affiliation><nlm:aff id="aff11"><addr-line>Department of Medicine, and</addr-line></nlm:aff><wicri:noCountry code="subfield">and</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="aff12"><addr-line>Department of Bioengineering, University of California San Diego, La Jolla, California, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Bioengineering, University of California San Diego, La Jolla, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Santos, Janine H" sort="Santos, Janine H" uniqKey="Santos J" first="Janine H." last="Santos">Janine H. Santos</name><affiliation><nlm:aff id="aff13"><addr-line>Laboratory of Molecular Carcinogenesis, and</addr-line></nlm:aff><wicri:noCountry code="subfield">and</wicri:noCountry></affiliation></author><author><name sortKey="Copeland, William C" sort="Copeland, William C" uniqKey="Copeland W" first="William C." last="Copeland">William C. Copeland</name><affiliation wicri:level="2"><nlm:aff id="aff14"><addr-line>Laboratory of Molecular Genetics, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Molecular Genetics, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Tice, Raymond R" sort="Tice, Raymond R" uniqKey="Tice R" first="Raymond R." last="Tice">Raymond R. Tice</name><affiliation wicri:level="2"><nlm:aff id="aff15"><addr-line>Biomolecular Screening Branch, Division of the National Toxicology Program, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Biomolecular Screening Branch, Division of the National Toxicology Program, NIEHS, NIH, DHHS, Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Balshaw, David M" sort="Balshaw, David M" uniqKey="Balshaw D" first="David M." last="Balshaw">David M. Balshaw</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Tyson, Frederick L" sort="Tyson, Frederick L" uniqKey="Tyson F" first="Frederick L." last="Tyson">Frederick L. Tyson</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author></analytic><series><title level="j">Environmental Health Perspectives</title><idno type="ISSN">0091-6765</idno><idno type="eISSN">1552-9924</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Background: Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP production but also through metabolites generated in the tricarboxylic acid cycle, as well as mitochondria–nuclear signaling related to mitochondria morphology, biogenesis, fission/fusion, mitophagy, apoptosis, and epigenetic regulation.</p><p>Objectives: We investigated the concept of bidirectional interactions between mitochondria and cellular pathways in response to environmental stress with a focus on epigenetic regulation, and we examined DNA repair and DDR pathways as examples of biological processes that respond to exogenous insults through changes in homeostasis and altered mitochondrial function.</p><p>Methods: The National Institute of Environmental Health Sciences sponsored the Workshop on Mitochondria, Energetics, Epigenetics, Environment, and DNA Damage Response on 25–26 March 2013. Here, we summarize key points and ideas emerging from this meeting.</p><p>Discussion: A more comprehensive understanding of signaling mechanisms (cross-talk) between the mitochondria and nucleus is central to elucidating the integration of mitochondrial functions with other cellular response pathways in modulating the effects of environmental agents. Recent studies have highlighted the importance of mitochondrial functions in epigenetic regulation and DDR with environmental stress. Development and application of novel technologies, enhanced experimental models, and a systems-type research approach will help to discern how environmentally induced mitochondrial dysfunction affects key mechanistic pathways.</p><p>Conclusions: Understanding mitochondria–cell signaling will provide insight into individual responses to environmental hazards, improving prediction of hazard and susceptibility to environmental stressors.</p><p>Citation: Shaughnessy DT, McAllister K, Worth L, Haugen AC, Meyer JN, Domann FE, Van Houten B, Mostoslavsky R, Bultman SJ, Baccarelli AA, Begley TJ, Sobol RW, Hirschey MD, Ideker T, Santos JH, Copeland WC, Tice RR, Balshaw DM, Tyson FL. 2014. Mitochondria, energetics, epigenetics, and cellular responses to stress. Environ Health Perspect 122:1271–1278; <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1289/ehp.1408418">http://dx.doi.org/10.1289/ehp.1408418</ext-link></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alexeyev, M" uniqKey="Alexeyev M">M Alexeyev</name></author><author><name sortKey="Shokolenko, I" uniqKey="Shokolenko I">I Shokolenko</name></author><author><name sortKey="Wilson, G" uniqKey="Wilson G">G Wilson</name></author><author><name sortKey="Ledoux, S" uniqKey="Ledoux S">S LeDoux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Andriamihaja, M" uniqKey="Andriamihaja M">M Andriamihaja</name></author><author><name sortKey="Chaumontet, C" uniqKey="Chaumontet C">C Chaumontet</name></author><author><name sortKey="Tome, D" uniqKey="Tome D">D Tome</name></author><author><name sortKey="Blachier, F" uniqKey="Blachier F">F Blachier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Attene Ramos, Ms" uniqKey="Attene Ramos M">MS Attene-Ramos</name></author><author><name sortKey="Huang, R" uniqKey="Huang R">R Huang</name></author><author><name sortKey="Michael, S" uniqKey="Michael S">S Michael</name></author><author><name sortKey="Witt, Kl" uniqKey="Witt K">KL Witt</name></author><author><name sortKey="Richard, A" uniqKey="Richard A">A Richard</name></author><author><name sortKey="Tice, Rr" uniqKey="Tice R">RR Tice</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baccarelli, A" uniqKey="Baccarelli A">A Baccarelli</name></author><author><name sortKey="Wright, Ro" uniqKey="Wright R">RO Wright</name></author><author><name sortKey="Bollati, V" uniqKey="Bollati V">V Bollati</name></author><author><name sortKey="Tarantini, L" uniqKey="Tarantini L">L Tarantini</name></author><author><name sortKey="Litonjua, Aa" uniqKey="Litonjua A">AA Litonjua</name></author><author><name sortKey="Suh, Hh" uniqKey="Suh H">HH Suh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Basu, Ss" uniqKey="Basu S">SS Basu</name></author><author><name sortKey="Blair, Ia" uniqKey="Blair I">IA Blair</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bellizzi, D" uniqKey="Bellizzi D">D Bellizzi</name></author><author><name sortKey="D Quila, P" uniqKey="D Quila P">P D’Aquila</name></author><author><name sortKey="Scafone, T" uniqKey="Scafone T">T Scafone</name></author><author><name sortKey="Giordano, M" uniqKey="Giordano M">M Giordano</name></author><author><name sortKey="Riso, V" uniqKey="Riso V">V Riso</name></author><author><name sortKey="Riccio, A" uniqKey="Riccio A">A Riccio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bess, As" uniqKey="Bess A">AS Bess</name></author><author><name sortKey="Crocker, Tl" uniqKey="Crocker T">TL Crocker</name></author><author><name sortKey="Ryde, It" uniqKey="Ryde I">IT Ryde</name></author><author><name sortKey="Meyer, Jn" uniqKey="Meyer J">JN Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bess, As" uniqKey="Bess A">AS Bess</name></author><author><name sortKey="Leung, Mc" uniqKey="Leung M">MC Leung</name></author><author><name sortKey="Ryde, It" uniqKey="Ryde I">IT Ryde</name></author><author><name sortKey="Rooney, Jp" uniqKey="Rooney J">JP Rooney</name></author><author><name sortKey="Hinton, De" uniqKey="Hinton D">DE Hinton</name></author><author><name sortKey="Meyer, Jn" uniqKey="Meyer J">JN Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourdineaud, Jp" uniqKey="Bourdineaud J">JP Bourdineaud</name></author><author><name sortKey="Rossignol, R" uniqKey="Rossignol R">R Rossignol</name></author><author><name sortKey="Brethes, D" uniqKey="Brethes D">D Brethes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Byun, Hm" uniqKey="Byun H">HM Byun</name></author><author><name sortKey="Panni, T" uniqKey="Panni T">T Panni</name></author><author><name sortKey="Motta, V" uniqKey="Motta V">V Motta</name></author><author><name sortKey="Hou, L" uniqKey="Hou L">L Hou</name></author><author><name sortKey="Nordio, F" uniqKey="Nordio F">F Nordio</name></author><author><name sortKey="Apostoli, P" uniqKey="Apostoli P">P Apostoli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cai, L" uniqKey="Cai L">L Cai</name></author><author><name sortKey="Sutter Benjamin, M" uniqKey="Sutter Benjamin M">M Sutter Benjamin</name></author><author><name sortKey="Li, B" uniqKey="Li B">B Li</name></author><author><name sortKey="Tu Benjamin, P" uniqKey="Tu Benjamin P">P Tu Benjamin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carling, Pj" uniqKey="Carling P">PJ Carling</name></author><author><name sortKey="Cree, Lm" uniqKey="Cree L">LM Cree</name></author><author><name sortKey="Chinnery, Pf" uniqKey="Chinnery P">PF Chinnery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carugno, M" uniqKey="Carugno M">M Carugno</name></author><author><name sortKey="Pesatori, Ac" uniqKey="Pesatori A">AC Pesatori</name></author><author><name sortKey="Dioni, L" uniqKey="Dioni L">L Dioni</name></author><author><name sortKey="Hoxha, M" uniqKey="Hoxha M">M Hoxha</name></author><author><name sortKey="Bollati, V" uniqKey="Bollati V">V Bollati</name></author><author><name sortKey="Albetti, B" uniqKey="Albetti B">B Albetti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Z" uniqKey="Cheng Z">Z Cheng</name></author><author><name sortKey="Ristow, M" uniqKey="Ristow M">M Ristow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cherry, Ab" uniqKey="Cherry A">AB Cherry</name></author><author><name sortKey="Gagne, Ke" uniqKey="Gagne K">KE Gagne</name></author><author><name sortKey="Mcloughlin, Em" uniqKey="Mcloughlin E">EM McLoughlin</name></author><author><name sortKey="Baccei, A" uniqKey="Baccei A">A Baccei</name></author><author><name sortKey="Gorman, B" uniqKey="Gorman B">B Gorman</name></author><author><name sortKey="Hartung, O" uniqKey="Hartung O">O Hartung</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cossarizza, A" uniqKey="Cossarizza A">A Cossarizza</name></author><author><name sortKey="Moyle, G" uniqKey="Moyle G">G Moyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cymerman, Ia" uniqKey="Cymerman I">IA Cymerman</name></author><author><name sortKey="Chung, I" uniqKey="Chung I">I Chung</name></author><author><name sortKey="Beckmann, Bm" uniqKey="Beckmann B">BM Beckmann</name></author><author><name sortKey="Bujnicki, Jm" uniqKey="Bujnicki J">JM Bujnicki</name></author><author><name sortKey="Meiss, G" uniqKey="Meiss G">G Meiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cyr, Ar" uniqKey="Cyr A">AR Cyr</name></author><author><name sortKey="Domann, Fe" uniqKey="Domann F">FE Domann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debattisti, V" uniqKey="Debattisti V">V Debattisti</name></author><author><name sortKey="Scorrano, L" uniqKey="Scorrano L">L Scorrano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Desouki, Mm" uniqKey="Desouki M">MM Desouki</name></author><author><name sortKey="Kulawiec, M" uniqKey="Kulawiec M">M Kulawiec</name></author><author><name sortKey="Bansal, S" uniqKey="Bansal S">S Bansal</name></author><author><name sortKey="Das, Gm" uniqKey="Das G">GM Das</name></author><author><name sortKey="Singh, Kk" uniqKey="Singh K">KK Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ditch, S" uniqKey="Ditch S">S Ditch</name></author><author><name sortKey="Paull, Tt" uniqKey="Paull T">TT Paull</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donohoe, Dr" uniqKey="Donohoe D">DR Donohoe</name></author><author><name sortKey="Bultman, Sj" uniqKey="Bultman S">SJ Bultman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Donohoe, Dr" uniqKey="Donohoe D">DR Donohoe</name></author><author><name sortKey="Garge, N" uniqKey="Garge N">N Garge</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Sun, W" uniqKey="Sun W">W Sun</name></author><author><name sortKey="O Onnell, Tm" uniqKey="O Onnell T">TM O’Connell</name></author><author><name sortKey="Bunger, Mk" uniqKey="Bunger M">MK Bunger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dzitoyeva, S" uniqKey="Dzitoyeva S">S Dzitoyeva</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Manev, H" uniqKey="Manev H">H Manev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fariss, Mw" uniqKey="Fariss M">MW Fariss</name></author><author><name sortKey="Chan, Cb" uniqKey="Chan C">CB Chan</name></author><author><name sortKey="Patel, M" uniqKey="Patel M">M Patel</name></author><author><name sortKey="Van Houten, B" uniqKey="Van Houten B">B Van Houten</name></author><author><name sortKey="Orrenius, S" uniqKey="Orrenius S">S Orrenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Figge, Mt" uniqKey="Figge M">MT Figge</name></author><author><name sortKey="Reichert, As" uniqKey="Reichert A">AS Reichert</name></author><author><name sortKey="Meyer Hermann, M" uniqKey="Meyer Hermann M">M Meyer-Hermann</name></author><author><name sortKey="Osiewacz, Hd" uniqKey="Osiewacz H">HD Osiewacz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Finkel, T" uniqKey="Finkel T">T Finkel</name></author><author><name sortKey="Deng, Cx" uniqKey="Deng C">CX Deng</name></author><author><name sortKey="Mostoslavsky, R" uniqKey="Mostoslavsky R">R Mostoslavsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flint, J" uniqKey="Flint J">J Flint</name></author><author><name sortKey="Eskin, E" uniqKey="Eskin E">E Eskin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fujikura, J" uniqKey="Fujikura J">J Fujikura</name></author><author><name sortKey="Nakao, K" uniqKey="Nakao K">K Nakao</name></author><author><name sortKey="Sone, M" uniqKey="Sone M">M Sone</name></author><author><name sortKey="Noguchi, M" uniqKey="Noguchi M">M Noguchi</name></author><author><name sortKey="Mori, E" uniqKey="Mori E">E Mori</name></author><author><name sortKey="Naito, M" uniqKey="Naito M">M Naito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furda, Am" uniqKey="Furda A">AM Furda</name></author><author><name sortKey="Bess, As" uniqKey="Bess A">AS Bess</name></author><author><name sortKey="Meyer, Jn" uniqKey="Meyer J">JN Meyer</name></author><author><name sortKey="Van Houten, B" uniqKey="Van Houten B">B Van Houten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gravel, Sp" uniqKey="Gravel S">SP Gravel</name></author><author><name sortKey="Andrzejewski, S" uniqKey="Andrzejewski S">S Andrzejewski</name></author><author><name sortKey="Avizonis, D" uniqKey="Avizonis D">D Avizonis</name></author><author><name sortKey="St Pierre, J" uniqKey="St Pierre J">J St-Pierre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Mx" uniqKey="Guan M">MX Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guenole, A" uniqKey="Guenole A">A Guenole</name></author><author><name sortKey="Srivas, R" uniqKey="Srivas R">R Srivas</name></author><author><name sortKey="Vreeken, K" uniqKey="Vreeken K">K Vreeken</name></author><author><name sortKey="Wang, Zz" uniqKey="Wang Z">ZZ Wang</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Krogan, Nj" uniqKey="Krogan N">NJ Krogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamalainen, Rh" uniqKey="Hamalainen R">RH Hamalainen</name></author><author><name sortKey="Manninen, T" uniqKey="Manninen T">T Manninen</name></author><author><name sortKey="Koivumaki, H" uniqKey="Koivumaki H">H Koivumaki</name></author><author><name sortKey="Kislin, M" uniqKey="Kislin M">M Kislin</name></author><author><name sortKey="Otonkoski, T" uniqKey="Otonkoski T">T Otonkoski</name></author><author><name sortKey="Suomalainen, A" uniqKey="Suomalainen A">A Suomalainen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanahan, D" uniqKey="Hanahan D">D Hanahan</name></author><author><name sortKey="Weinberg, Ra" uniqKey="Weinberg R">RA Weinberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirschey, Md" uniqKey="Hirschey M">MD Hirschey</name></author><author><name sortKey="Shimazu, T" uniqKey="Shimazu T">T Shimazu</name></author><author><name sortKey="Jing, E" uniqKey="Jing E">E Jing</name></author><author><name sortKey="Grueter, Ca" uniqKey="Grueter C">CA Grueter</name></author><author><name sortKey="Collins, Am" uniqKey="Collins A">AM Collins</name></author><author><name sortKey="Aouizerat, B" uniqKey="Aouizerat B">B Aouizerat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hitchler, Mj" uniqKey="Hitchler M">MJ Hitchler</name></author><author><name sortKey="Domann, Fe" uniqKey="Domann F">FE Domann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hitchler, Mj" uniqKey="Hitchler M">MJ Hitchler</name></author><author><name sortKey="Domann, Fe" uniqKey="Domann F">FE Domann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, J" uniqKey="Ho J">J Ho</name></author><author><name sortKey="De Moura, Mb" uniqKey="De Moura M">MB de Moura</name></author><author><name sortKey="Lin, Y" uniqKey="Lin Y">Y Lin</name></author><author><name sortKey="Vincent, G" uniqKey="Vincent G">G Vincent</name></author><author><name sortKey="Thorne, S" uniqKey="Thorne S">S Thorne</name></author><author><name sortKey="Duncan, Lm" uniqKey="Duncan L">LM Duncan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hong, Ee" uniqKey="Hong E">EE Hong</name></author><author><name sortKey="Okitsu, Cy" uniqKey="Okitsu C">CY Okitsu</name></author><author><name sortKey="Smith, Ad" uniqKey="Smith A">AD Smith</name></author><author><name sortKey="Hsieh, Cl" uniqKey="Hsieh C">CL Hsieh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, L" uniqKey="Hou L">L Hou</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Dioni, L" uniqKey="Dioni L">L Dioni</name></author><author><name sortKey="Barretta, F" uniqKey="Barretta F">F Barretta</name></author><author><name sortKey="Dou, C" uniqKey="Dou C">C Dou</name></author><author><name sortKey="Zheng, Y" uniqKey="Zheng Y">Y Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, L" uniqKey="Hou L">L Hou</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Baccarelli, A" uniqKey="Baccarelli A">A Baccarelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hou, L" uniqKey="Hou L">L Hou</name></author><author><name sortKey="Zhu, Zz" uniqKey="Zhu Z">ZZ Zhu</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Nordio, F" uniqKey="Nordio F">F Nordio</name></author><author><name sortKey="Bonzini, M" uniqKey="Bonzini M">M Bonzini</name></author><author><name sortKey="Schwartz, J" uniqKey="Schwartz J">J Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hudson, Mm" uniqKey="Hudson M">MM Hudson</name></author><author><name sortKey="Ness, Kk" uniqKey="Ness K">KK Ness</name></author><author><name sortKey="Gurney, Jg" uniqKey="Gurney J">JG Gurney</name></author><author><name sortKey="Mulrooney, Da" uniqKey="Mulrooney D">DA Mulrooney</name></author><author><name sortKey="Chemaitilly, W" uniqKey="Chemaitilly W">W Chemaitilly</name></author><author><name sortKey="Krull, Kr" uniqKey="Krull K">KR Krull</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iacobazzi, V" uniqKey="Iacobazzi V">V Iacobazzi</name></author><author><name sortKey="Castegna, A" uniqKey="Castegna A">A Castegna</name></author><author><name sortKey="Infantino, V" uniqKey="Infantino V">V Infantino</name></author><author><name sortKey="Andria, G" uniqKey="Andria G">G Andria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ideker, T" uniqKey="Ideker T">T Ideker</name></author><author><name sortKey="Krogan, Nj" uniqKey="Krogan N">NJ Krogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jansen, Rp" uniqKey="Jansen R">RP Jansen</name></author><author><name sortKey="De Boer, K" uniqKey="De Boer K">K de Boer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Janssen, Bg" uniqKey="Janssen B">BG Janssen</name></author><author><name sortKey="Munters, E" uniqKey="Munters E">E Munters</name></author><author><name sortKey="Pieters, N" uniqKey="Pieters N">N Pieters</name></author><author><name sortKey="Smeets, K" uniqKey="Smeets K">K Smeets</name></author><author><name sortKey="Cox, B" uniqKey="Cox B">B Cox</name></author><author><name sortKey="Cuypers, A" uniqKey="Cuypers A">A Cuypers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jelezcova, E" uniqKey="Jelezcova E">E Jelezcova</name></author><author><name sortKey="Trivedi, Rn" uniqKey="Trivedi R">RN Trivedi</name></author><author><name sortKey="Wang, Xh" uniqKey="Wang X">XH Wang</name></author><author><name sortKey="Tang, Jb" uniqKey="Tang J">JB Tang</name></author><author><name sortKey="Brown, Ar" uniqKey="Brown A">AR Brown</name></author><author><name sortKey="Goellner, Em" uniqKey="Goellner E">EM Goellner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Dt" uniqKey="Johnson D">DT Johnson</name></author><author><name sortKey="Harris, Ra" uniqKey="Harris R">RA Harris</name></author><author><name sortKey="French, S" uniqKey="French S">S French</name></author><author><name sortKey="Blair, Pv" uniqKey="Blair P">PV Blair</name></author><author><name sortKey="You, J" uniqKey="You J">J You</name></author><author><name sortKey="Bemis, Kg" uniqKey="Bemis K">KG Bemis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kazak, L" uniqKey="Kazak L">L Kazak</name></author><author><name sortKey="Reyes, A" uniqKey="Reyes A">A Reyes</name></author><author><name sortKey="Holt, Ij" uniqKey="Holt I">IJ Holt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kembro, Jm" uniqKey="Kembro J">JM Kembro</name></author><author><name sortKey="Aon, Ma" uniqKey="Aon M">MA Aon</name></author><author><name sortKey="Winslow, Rl" uniqKey="Winslow R">RL Winslow</name></author><author><name sortKey="O Ourke, B" uniqKey="O Ourke B">B O’Rourke</name></author><author><name sortKey="Cortassa, S" uniqKey="Cortassa S">S Cortassa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ladurner, Ag" uniqKey="Ladurner A">AG Ladurner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Layec, G" uniqKey="Layec G">G Layec</name></author><author><name sortKey="Malucelli, E" uniqKey="Malucelli E">E Malucelli</name></author><author><name sortKey="Le Fur, Y" uniqKey="Le Fur Y">Y Le Fur</name></author><author><name sortKey="Manners, D" uniqKey="Manners D">D Manners</name></author><author><name sortKey="Yashiro, K" uniqKey="Yashiro K">K Yashiro</name></author><author><name sortKey="Testa, C" uniqKey="Testa C">C Testa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leschelle, X" uniqKey="Leschelle X">X Leschelle</name></author><author><name sortKey="Delpal, S" uniqKey="Delpal S">S Delpal</name></author><author><name sortKey="Goubern, M" uniqKey="Goubern M">M Goubern</name></author><author><name sortKey="Blottiere, Hm" uniqKey="Blottiere H">HM Blottière</name></author><author><name sortKey="Blachier, F" uniqKey="Blachier F">F Blachier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leung, Mc" uniqKey="Leung M">MC Leung</name></author><author><name sortKey="Rooney, Jp" uniqKey="Rooney J">JP Rooney</name></author><author><name sortKey="Ryde, It" uniqKey="Ryde I">IT Ryde</name></author><author><name sortKey="Bernal, Aj" uniqKey="Bernal A">AJ Bernal</name></author><author><name sortKey="Bess, As" uniqKey="Bess A">AS Bess</name></author><author><name sortKey="Crocker, Tl" uniqKey="Crocker T">TL Crocker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, C" uniqKey="Lu C">C Lu</name></author><author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maher, Ea" uniqKey="Maher E">EA Maher</name></author><author><name sortKey="Marin Valencia, I" uniqKey="Marin Valencia I">I Marin-Valencia</name></author><author><name sortKey="Bachoo, Rm" uniqKey="Bachoo R">RM Bachoo</name></author><author><name sortKey="Mashimo, T" uniqKey="Mashimo T">T Mashimo</name></author><author><name sortKey="Raisanen, J" uniqKey="Raisanen J">J Raisanen</name></author><author><name sortKey="Hatanpaa, Kj" uniqKey="Hatanpaa K">KJ Hatanpaa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mandal, Sm" uniqKey="Mandal S">SM Mandal</name></author><author><name sortKey="Hegde, Ml" uniqKey="Hegde M">ML Hegde</name></author><author><name sortKey="Chatterjee, A" uniqKey="Chatterjee A">A Chatterjee</name></author><author><name sortKey="Hegde, Pm" uniqKey="Hegde P">PM Hegde</name></author><author><name sortKey="Szczesny, B" uniqKey="Szczesny B">B Szczesny</name></author><author><name sortKey="Banerjee, D" uniqKey="Banerjee D">D Banerjee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martinez Pastor, B" uniqKey="Martinez Pastor B">B Martinez-Pastor</name></author><author><name sortKey="Cosentino, C" uniqKey="Cosentino C">C Cosentino</name></author><author><name sortKey="Mostoslavsky, R" uniqKey="Mostoslavsky R">R Mostoslavsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maynard, S" uniqKey="Maynard S">S Maynard</name></author><author><name sortKey="De Souza Pinto, Nc" uniqKey="De Souza Pinto N">NC de Souza-Pinto</name></author><author><name sortKey="Scheibye Knudsen, M" uniqKey="Scheibye Knudsen M">M Scheibye-Knudsen</name></author><author><name sortKey="Bohr, Va" uniqKey="Bohr V">VA Bohr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meunier, B" uniqKey="Meunier B">B Meunier</name></author><author><name sortKey="Fisher, N" uniqKey="Fisher N">N Fisher</name></author><author><name sortKey="Ransac, S" uniqKey="Ransac S">S Ransac</name></author><author><name sortKey="Mazat, Jp" uniqKey="Mazat J">JP Mazat</name></author><author><name sortKey="Brasseur, G" uniqKey="Brasseur G">G Brasseur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, Jn" uniqKey="Meyer J">JN Meyer</name></author><author><name sortKey="Leung, Mc" uniqKey="Leung M">MC Leung</name></author><author><name sortKey="Rooney, Jp" uniqKey="Rooney J">JP Rooney</name></author><author><name sortKey="Sendoel, A" uniqKey="Sendoel A">A Sendoel</name></author><author><name sortKey="Hengartner, Mo" uniqKey="Hengartner M">MO Hengartner</name></author><author><name sortKey="Kisby, Ge" uniqKey="Kisby G">GE Kisby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mootha, Vk" uniqKey="Mootha V">VK Mootha</name></author><author><name sortKey="Lindgren, Cm" uniqKey="Lindgren C">CM Lindgren</name></author><author><name sortKey="Eriksson, Kf" uniqKey="Eriksson K">KF Eriksson</name></author><author><name sortKey="Subramanian, A" uniqKey="Subramanian A">A Subramanian</name></author><author><name sortKey="Sihag, S" uniqKey="Sihag S">S Sihag</name></author><author><name sortKey="Lehar, J" uniqKey="Lehar J">J Lehar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nachbauer, W" uniqKey="Nachbauer W">W Nachbauer</name></author><author><name sortKey="Boesch, S" uniqKey="Boesch S">S Boesch</name></author><author><name sortKey="Schneider, R" uniqKey="Schneider R">R Schneider</name></author><author><name sortKey="Eigentler, A" uniqKey="Eigentler A">A Eigentler</name></author><author><name sortKey="Wanschitz, J" uniqKey="Wanschitz J">J Wanschitz</name></author><author><name sortKey="Poewe, W" uniqKey="Poewe W">W Poewe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakajima, Ec" uniqKey="Nakajima E">EC Nakajima</name></author><author><name sortKey="Van Houten, B" uniqKey="Van Houten B">B Van Houten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nieman, Km" uniqKey="Nieman K">KM Nieman</name></author><author><name sortKey="Romero, Il" uniqKey="Romero I">IL Romero</name></author><author><name sortKey="Van Houten, B" uniqKey="Van Houten B">B Van Houten</name></author><author><name sortKey="Lengyel, E" uniqKey="Lengyel E">E Lengyel</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Papadopoulos, V" uniqKey="Papadopoulos V">V Papadopoulos</name></author><author><name sortKey="Miller, Wl" uniqKey="Miller W">WL Miller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pavanello, S" uniqKey="Pavanello S">S Pavanello</name></author><author><name sortKey="Dioni, L" uniqKey="Dioni L">L Dioni</name></author><author><name sortKey="Hoxha, M" uniqKey="Hoxha M">M Hoxha</name></author><author><name sortKey="Fedeli, U" uniqKey="Fedeli U">U Fedeli</name></author><author><name sortKey="Mielzynska Svach, D" uniqKey="Mielzynska Svach D">D Mielzynska-Svach</name></author><author><name sortKey="Baccarelli, Aa" uniqKey="Baccarelli A">AA Baccarelli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinho, Br" uniqKey="Pinho B">BR Pinho</name></author><author><name sortKey="Santos, Mm" uniqKey="Santos M">MM Santos</name></author><author><name sortKey="Fonseca Silva, A" uniqKey="Fonseca Silva A">A Fonseca-Silva</name></author><author><name sortKey="Valentao, P" uniqKey="Valentao P">P Valentão</name></author><author><name sortKey="Andrade, Pb" uniqKey="Andrade P">PB Andrade</name></author><author><name sortKey="Oliveira, Jm" uniqKey="Oliveira J">JM Oliveira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Poirier, Mc" uniqKey="Poirier M">MC Poirier</name></author><author><name sortKey="Divi, Rl" uniqKey="Divi R">RL Divi</name></author><author><name sortKey="Al Harthi, L" uniqKey="Al Harthi L">L Al-Harthi</name></author><author><name sortKey="Olivero, Oa" uniqKey="Olivero O">OA Olivero</name></author><author><name sortKey="Nguyen, V" uniqKey="Nguyen V">V Nguyen</name></author><author><name sortKey="Walker, B" uniqKey="Walker B">B Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, W" uniqKey="Qian W">W Qian</name></author><author><name sortKey="Choi, S" uniqKey="Choi S">S Choi</name></author><author><name sortKey="Gibson, Ga" uniqKey="Gibson G">GA Gibson</name></author><author><name sortKey="Watkins, Sc" uniqKey="Watkins S">SC Watkins</name></author><author><name sortKey="Bakkenist, Cj" uniqKey="Bakkenist C">CJ Bakkenist</name></author><author><name sortKey="Van Houten, B" uniqKey="Van Houten B">B Van Houten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, W" uniqKey="Qian W">W Qian</name></author><author><name sortKey="Van Houten, B" uniqKey="Van Houten B">B Van Houten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sauer, U" uniqKey="Sauer U">U Sauer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schulze, A" uniqKey="Schulze A">A Schulze</name></author><author><name sortKey="Harris, Al" uniqKey="Harris A">AL Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sebastian, C" uniqKey="Sebastian C">C Sebastian</name></author><author><name sortKey="Zwaans, Bm" uniqKey="Zwaans B">BM Zwaans</name></author><author><name sortKey="Silberman, Dm" uniqKey="Silberman D">DM Silberman</name></author><author><name sortKey="Gymrek, M" uniqKey="Gymrek M">M Gymrek</name></author><author><name sortKey="Goren, A" uniqKey="Goren A">A Goren</name></author><author><name sortKey="Zhong, L" uniqKey="Zhong L">L Zhong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharma, Nk" uniqKey="Sharma N">NK Sharma</name></author><author><name sortKey="Lebedeva, M" uniqKey="Lebedeva M">M Lebedeva</name></author><author><name sortKey="Thomas, T" uniqKey="Thomas T">T Thomas</name></author><author><name sortKey="Kovalenko, Oa" uniqKey="Kovalenko O">OA Kovalenko</name></author><author><name sortKey="Stumpf, Jd" uniqKey="Stumpf J">JD Stumpf</name></author><author><name sortKey="Shadel, Gs" uniqKey="Shadel G">GS Shadel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shock, Ls" uniqKey="Shock L">LS Shock</name></author><author><name sortKey="Thakkar, Pv" uniqKey="Thakkar P">PV Thakkar</name></author><author><name sortKey="Peterson, Ej" uniqKey="Peterson E">EJ Peterson</name></author><author><name sortKey="Moran, Rg" uniqKey="Moran R">RG Moran</name></author><author><name sortKey="Taylor, Sm" uniqKey="Taylor S">SM Taylor</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shoubridge, Ea" uniqKey="Shoubridge E">EA Shoubridge</name></author><author><name sortKey="Wai, T" uniqKey="Wai T">T Wai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silva, Mf" uniqKey="Silva M">MF Silva</name></author><author><name sortKey="Aires, Cc" uniqKey="Aires C">CC Aires</name></author><author><name sortKey="Luis, Pb" uniqKey="Luis P">PB Luis</name></author><author><name sortKey="Ruiter, Jp" uniqKey="Ruiter J">JP Ruiter</name></author><author><name sortKey="Ijlst, L" uniqKey="Ijlst L">L IJlst</name></author><author><name sortKey="Duran, M" uniqKey="Duran M">M Duran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simsek, D" uniqKey="Simsek D">D Simsek</name></author><author><name sortKey="Brunet, E" uniqKey="Brunet E">E Brunet</name></author><author><name sortKey="Wong, Sy" uniqKey="Wong S">SY Wong</name></author><author><name sortKey="Katyal, S" uniqKey="Katyal S">S Katyal</name></author><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y Gao</name></author><author><name sortKey="Mckinnon, Pj" uniqKey="Mckinnon P">PJ McKinnon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smiraglia, Dj" uniqKey="Smiraglia D">DJ Smiraglia</name></author><author><name sortKey="Kulawiec, M" uniqKey="Kulawiec M">M Kulawiec</name></author><author><name sortKey="Bistulfi, Gl" uniqKey="Bistulfi G">GL Bistulfi</name></author><author><name sortKey="Gupta, Sg" uniqKey="Gupta S">SG Gupta</name></author><author><name sortKey="Singh, Kk" uniqKey="Singh K">KK Singh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srivas, R" uniqKey="Srivas R">R Srivas</name></author><author><name sortKey="Costelloe, T" uniqKey="Costelloe T">T Costelloe</name></author><author><name sortKey="Carvunis, Ar" uniqKey="Carvunis A">AR Carvunis</name></author><author><name sortKey="Sarkar, S" uniqKey="Sarkar S">S Sarkar</name></author><author><name sortKey="Malta, E" uniqKey="Malta E">E Malta</name></author><author><name sortKey="Sun, Sm" uniqKey="Sun S">SM Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Subramanian, A" uniqKey="Subramanian A">A Subramanian</name></author><author><name sortKey="Tamayo, P" uniqKey="Tamayo P">P Tamayo</name></author><author><name sortKey="Mootha, Vk" uniqKey="Mootha V">VK Mootha</name></author><author><name sortKey="Mukherjee, S" uniqKey="Mukherjee S">S Mukherjee</name></author><author><name sortKey="Ebert, Bl" uniqKey="Ebert B">BL Ebert</name></author><author><name sortKey="Gillette, Ma" uniqKey="Gillette M">MA Gillette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suen, Df" uniqKey="Suen D">DF Suen</name></author><author><name sortKey="Norris, Kl" uniqKey="Norris K">KL Norris</name></author><author><name sortKey="Youle, Rj" uniqKey="Youle R">RJ Youle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tait, Sw" uniqKey="Tait S">SW Tait</name></author><author><name sortKey="Green, Dr" uniqKey="Green D">DR Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tait, Sw" uniqKey="Tait S">SW Tait</name></author><author><name sortKey="Green, Dr" uniqKey="Green D">DR Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takahashi, H" uniqKey="Takahashi H">H Takahashi</name></author><author><name sortKey="Mccaffery, Jm" uniqKey="Mccaffery J">JM McCaffery</name></author><author><name sortKey="Irizarry, Ra" uniqKey="Irizarry R">RA Irizarry</name></author><author><name sortKey="Boeke, Jd" uniqKey="Boeke J">JD Boeke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Jb" uniqKey="Tang J">JB Tang</name></author><author><name sortKey="Goellner, Em" uniqKey="Goellner E">EM Goellner</name></author><author><name sortKey="Wang, Xh" uniqKey="Wang X">XH Wang</name></author><author><name sortKey="Trivedi, Rn" uniqKey="Trivedi R">RN Trivedi</name></author><author><name sortKey="St Croix, Cm" uniqKey="St Croix C">CM St Croix</name></author><author><name sortKey="Jelezcova, E" uniqKey="Jelezcova E">E Jelezcova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tann, Aw" uniqKey="Tann A">AW Tann</name></author><author><name sortKey="Boldogh, I" uniqKey="Boldogh I">I Boldogh</name></author><author><name sortKey="Meiss, G" uniqKey="Meiss G">G Meiss</name></author><author><name sortKey="Qian, W" uniqKey="Qian W">W Qian</name></author><author><name sortKey="Van Houten, B" uniqKey="Van Houten B">B Van Houten</name></author><author><name sortKey="Mitra, S" uniqKey="Mitra S">S Mitra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Turcan, S" uniqKey="Turcan S">S Turcan</name></author><author><name sortKey="Rohle, D" uniqKey="Rohle D">D Rohle</name></author><author><name sortKey="Goenka, A" uniqKey="Goenka A">A Goenka</name></author><author><name sortKey="Walsh, La" uniqKey="Walsh L">LA Walsh</name></author><author><name sortKey="Fang, F" uniqKey="Fang F">F Fang</name></author><author><name sortKey="Yilmaz, E" uniqKey="Yilmaz E">E Yilmaz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vafai, Sb" uniqKey="Vafai S">SB Vafai</name></author><author><name sortKey="Mootha, Vk" uniqKey="Mootha V">VK Mootha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valentin Vega, Ya" uniqKey="Valentin Vega Y">YA Valentin-Vega</name></author><author><name sortKey="Kastan, Mb" uniqKey="Kastan M">MB Kastan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valentin Vega, Ya" uniqKey="Valentin Vega Y">YA Valentin-Vega</name></author><author><name sortKey="Maclean, Kh" uniqKey="Maclean K">KH Maclean</name></author><author><name sortKey="Tait Mulder, J" uniqKey="Tait Mulder J">J Tait-Mulder</name></author><author><name sortKey="Milasta, S" uniqKey="Milasta S">S Milasta</name></author><author><name sortKey="Steeves, M" uniqKey="Steeves M">M Steeves</name></author><author><name sortKey="Dorsey, Fc" uniqKey="Dorsey F">FC Dorsey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Houten, B" uniqKey="Van Houten B">B Van Houten</name></author><author><name sortKey="Woshner, V" uniqKey="Woshner V">V Woshner</name></author><author><name sortKey="Santos, Jh" uniqKey="Santos J">JH Santos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vander Heiden, Mg" uniqKey="Vander Heiden M">MG Vander Heiden</name></author><author><name sortKey="Cantley, Lc" uniqKey="Cantley L">LC Cantley</name></author><author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wallace, Dc" uniqKey="Wallace D">DC Wallace</name></author><author><name sortKey="Fan, W" uniqKey="Fan W">W Fan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ward, Ps" uniqKey="Ward P">PS Ward</name></author><author><name sortKey="Cross, Jr" uniqKey="Cross J">JR Cross</name></author><author><name sortKey="Lu, C" uniqKey="Lu C">C Lu</name></author><author><name sortKey="Weigert, O" uniqKey="Weigert O">O Weigert</name></author><author><name sortKey="Abel Wahab, O" uniqKey="Abel Wahab O">O Abel-Wahab</name></author><author><name sortKey="Levine, Rl" uniqKey="Levine R">RL Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wellen, Ke" uniqKey="Wellen K">KE Wellen</name></author><author><name sortKey="Hatzivassiliou, G" uniqKey="Hatzivassiliou G">G Hatzivassiliou</name></author><author><name sortKey="Sachdeva, Um" uniqKey="Sachdeva U">UM Sachdeva</name></author><author><name sortKey="Bui, Tv" uniqKey="Bui T">TV Bui</name></author><author><name sortKey="Cross, Jr" uniqKey="Cross J">JR Cross</name></author><author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wittkopp, S" uniqKey="Wittkopp S">S Wittkopp</name></author><author><name sortKey="Staimer, N" uniqKey="Staimer N">N Staimer</name></author><author><name sortKey="Tjoa, T" uniqKey="Tjoa T">T Tjoa</name></author><author><name sortKey="Gillen, D" uniqKey="Gillen D">D Gillen</name></author><author><name sortKey="Daher, N" uniqKey="Daher N">N Daher</name></author><author><name sortKey="Shafer, M" uniqKey="Shafer M">M Shafer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zamboni, N" uniqKey="Zamboni N">N Zamboni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zemirli, N" uniqKey="Zemirli N">N Zemirli</name></author><author><name sortKey="Arnoult, D" uniqKey="Arnoult D">D Arnoult</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name></author><author><name sortKey="Nuebel, E" uniqKey="Nuebel E">E Nuebel</name></author><author><name sortKey="Daley, Gq" uniqKey="Daley G">GQ Daley</name></author><author><name sortKey="Koehler, Cm" uniqKey="Koehler C">CM Koehler</name></author><author><name sortKey="Teitell, Ma" uniqKey="Teitell M">MA Teitell</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>Caroline du Nord</li><li>Iowa</li><li>Massachusetts</li><li>Pennsylvanie</li><li>État de New York</li></region><settlement><li>Chapel Hill (Caroline du Nord)</li><li>Iowa City</li></settlement><orgName><li>Université de Caroline du Nord à Chapel Hill</li><li>Université de l'Iowa</li></orgName></list><tree><noCountry><name sortKey="Santos, Janine H" sort="Santos, Janine H" uniqKey="Santos J" first="Janine H." last="Santos">Janine H. Santos</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Shaughnessy, Daniel T" sort="Shaughnessy, Daniel T" uniqKey="Shaughnessy D" first="Daniel T." last="Shaughnessy">Daniel T. Shaughnessy</name></region><name sortKey="Baccarelli, Andrea A" sort="Baccarelli, Andrea A" uniqKey="Baccarelli A" first="Andrea A." last="Baccarelli">Andrea A. Baccarelli</name><name sortKey="Balshaw, David M" sort="Balshaw, David M" uniqKey="Balshaw D" first="David M." last="Balshaw">David M. Balshaw</name><name sortKey="Begley, Thomas J" sort="Begley, Thomas J" uniqKey="Begley T" first="Thomas J." last="Begley">Thomas J. Begley</name><name sortKey="Bultman, Scott J" sort="Bultman, Scott J" uniqKey="Bultman S" first="Scott J." last="Bultman">Scott J. Bultman</name><name sortKey="Copeland, William C" sort="Copeland, William C" uniqKey="Copeland W" first="William C." last="Copeland">William C. Copeland</name><name sortKey="Domann, Frederick E" sort="Domann, Frederick E" uniqKey="Domann F" first="Frederick E." last="Domann">Frederick E. Domann</name><name sortKey="Haugen, Astrid C" sort="Haugen, Astrid C" uniqKey="Haugen A" first="Astrid C." last="Haugen">Astrid C. Haugen</name><name sortKey="Hirschey, Matthew D" sort="Hirschey, Matthew D" uniqKey="Hirschey M" first="Matthew D." last="Hirschey">Matthew D. Hirschey</name><name sortKey="Ideker, Trey" sort="Ideker, Trey" uniqKey="Ideker T" first="Trey" last="Ideker">Trey Ideker</name><name sortKey="Mcallister, Kimberly" sort="Mcallister, Kimberly" uniqKey="Mcallister K" first="Kimberly" last="Mcallister">Kimberly Mcallister</name><name sortKey="Meyer, Joel N" sort="Meyer, Joel N" uniqKey="Meyer J" first="Joel N." last="Meyer">Joel N. Meyer</name><name sortKey="Mostoslavsky, Raul" sort="Mostoslavsky, Raul" uniqKey="Mostoslavsky R" first="Raul" last="Mostoslavsky">Raul Mostoslavsky</name><name sortKey="Sobol, Robert W" sort="Sobol, Robert W" uniqKey="Sobol R" first="Robert W." last="Sobol">Robert W. Sobol</name><name sortKey="Sobol, Robert W" sort="Sobol, Robert W" uniqKey="Sobol R" first="Robert W." last="Sobol">Robert W. Sobol</name><name sortKey="Tice, Raymond R" sort="Tice, Raymond R" uniqKey="Tice R" first="Raymond R." last="Tice">Raymond R. Tice</name><name sortKey="Tyson, Frederick L" sort="Tyson, Frederick L" uniqKey="Tyson F" first="Frederick L." last="Tyson">Frederick L. Tyson</name><name sortKey="Van Houten, Bennett" sort="Van Houten, Bennett" uniqKey="Van Houten B" first="Bennett" last="Van Houten">Bennett Van Houten</name><name sortKey="Worth, Leroy" sort="Worth, Leroy" uniqKey="Worth L" first="Leroy" last="Worth">Leroy Worth</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002116 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002116 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4256704
|texte= Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25127496" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |